… In patients with SNCA mutations, the sympathetic denervation was most … cardiac sympathetic
denervation was documented in asymptomatic carriers of PARK genes, symptomatic OH in …

… abnormalities and myocardial sympathetic denervation are … severe in the asymptomatic
E46K-SNCA mutation carrier (A02… carriers, regardless of being symptomatic or asymptomatic. …

… failure with sympathetic denervation; and healthy volunteers (HVs). … An asymptomatic
carrier of a SNCA duplication also received … E46K mutation carrier, suggesting that peripheral …

… E46K mutation [8]. Furthermore, selective cardiac sympathetic denervation was found in
five of six carriers (including one asymptomatic subject) who underwent MIBG scintigraphy [9]. …

… the characteristics of cutaneous nerve p-α-syn or α-syn deposits and their … gene mutations.
This review can serve as a reference for the diagnosis and classification of PD based on α-…

… cardiac sympathetic denervation was found in symptomatic and asymptomatic carriers (… An
in vitro study using primary neuron cultures suggested the pathological E46K SNCA mutation …

… The PNS-first (RBD-positive) patients initially show cardiac sympathetic denervation …
symptomatic carriers (n = 4) and 2 of 3 asymptomatic carriers of the E46K PARK-1 mutation had …

… myocardial sympathetic denervation as measured by MIBG scintigraphy in patients with a
wide spectrum of genetic … , PARK1 symptomatic carriers of E46K mutation in the SNCA gene; …

… , E46K, H50Q, G51D, and A53T missense mutants in the presence of lipid vesicles. These
findings have important implications regarding the interplay between the lipids required for αS …

… Postural instability and gait disturbance were less frequent in patients with E46K mutation
or … with E46K mutation or SNCA triplication, as well as those with H50Q or A53T mutations. …